Fundamental understanding in structure - property relationship will be gained through systematically characterizing materials at length scales, ranging from molecular dimension to single crystal/particles, to powders, and to finished products. The UMN team's expertise in powder characterization and property enhancement through integrated crystal engineering and particle design will enable the development of both highly effective and easy-to-adopt strategies to solve manufacturing problems. The CIMSEPP team will advance and promote fundamental understanding of the material properties and interactions among drug(s) and additives at the molecular and particulate level as affected by manufacturing processes. Center research thrusts, designed for transformative impact, are: A) Particle and Crystal Engineering, B) Model Predictive Understanding of Materials and Product Performance, and C) Bioavailability Enhancement and Stability. The proposed research aims at developing a fundamental understanding of structure-function-performance of particulate-based drug products and their process engineering, paving the way for applying crystal and particle engineering towards enhancing drug bioavailability, manufacturability, product stability, and product quality. The Center will also positively impact students from under-represented minority groups, through training in cutting edge research methodologies, tech-transfer, innovation and entrepreneurship. Proposed material science based translational research is expected to have significant economic impact, due to improved product quality, reduced product failures, simplified manufacturing operations, and significantly reducing product development times and manufacturing costs. This Center aims to address these problems and the needs of industry through paradigm shifting mechanistic approach for developing predictive understanding of the impact of processes and material properties on product performance. These arise largely due to highly complex nature of pharmaceutical products that contain many different components, the inadequate understanding of the manufacturing processes, and lack of predictive tools to assess product performance from material properties. Yet, there are major problems, e.g., slowing market growth, long time and high costs of bringing a new drug to market, product quality, and drug shortages. The pharmaceutical sector in the USA is a major, trillion-dollar industry, having broad impacts on the health and well-being of the US population. This IUCRC planning project focuses on establishing a collaborative three-university center to advance fundamental materials science and engineering research for facilitating high quality drug product development. Primary Place of Performance Congressional District: Changquan Sun (Principal Investigator) Sponsored Research Office:.

Prakash Balan (703)292-5341 IIP Div Of Industrial Innovation & Partnersh ENG Directorate For Engineering

IIP Div Of Industrial Innovation & Partnersh Planning IUCRC at University of Minnesota-Twin Cities: Center for Integrated Material Science and Engineering for Pharmaceutical Products (CIMSEPP) NSF Org:

Crystal maker umn